Pathogenesis of spontaneous hypertension as a model for essential hypertension.

Pathogenesis of Essential Hypertension

T HE pathogenesis of essential hypertension, which accounts for 95 per cent of hypertensions seen clinically, is still unknown despite extensive research during the past 25 years. These studies, however, have indicated that there are neurogenic, electrolyte, endocrine, and renal changes in pathophysiology that may have pathogenetic significance for essential hypertension. These changes may be i...

Pathogenesis of essential hypertension.

Essential Hypertension – Pathogenesis and Pathophysiology

Population studies suggest the blood pressure (BP) is a continuous variable, with no absolute dividing line between normal and abnormal values1. High blood pressure is a leading risk factor for heart disease, stroke, and kidney failure. This correlation is more robust with systolic than with diastolic BP2. Even when BP is lowered by antihypertensive medication, the associated reduction in the i...

The rat with spontaneous genetic hypertension is not a suitable model of human essential hypertension.

Brief Reviews: Lipid-Membrane Interactions and the Pathogenesis of Ischemic Damage in the Myocardium. Arnold M. Katz and Frank C. Messineo 1 Role of Changes in Microsomal Calcium Uptake in the Effects of Reperfusion of Ca-Deprived Rat Hearts. Lauri E. Alto and Naranjan S. Dhalla 17 Reduction of Maximal Coronary Vasodilator Capacity in Conscious Dogs with Severe Right Ventricular Hypertrophy. Pa...

CONTROVERSIES IN CARDIOVASCULAR RESEARCH* The Rat with Spontaneous Genetic Hypertension is not a Suitable Model of Human Essential Hypertension

THE general availability of genetically hypertensive rats has provided the opportunity to investigators in diverse disciplines to study the many faces of hypertension and has quickened our appreciation of the complexities of disentangling the snarled hormonal, nervous, functional, and cardiovascular architectural interrelationships required to identify the causes of elevation of blood pressure....